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Esomeprazole magnesium (trihydrate)

Esomeprazole magnesium trihydrate ((S) -Omeprazole magnesium trihydrate) is a potent and orally active H+, K+-ATPase inhibitor. Esomeprazole magnesium trihydrate has the potential for upper intestinal disorders and gastroesophageal reflux disease research[1][2]. Esomeprazole magnesium trihydrate acts as an exosome inhibitor by blocking the exosome release via the inhibition of V-H+-ATPases[4].

Product Specifications

CAS Number

217087-09-7

Product Name Alternative

(S) -Omeprazole magnesium (trihydrate) ; (-) -Omeprazole magnesium (trihydrate)

UNSPSC

12352211

Hazard Statement

H302, H315, H319, H335

Target

Proton Pump

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel

Field of Research

Endocrinology; Cancer

Assay Protocol

https://www.medchemexpress.com/esomeprazole-magnesium-trihydrate.html

Purity

99.62

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

[H]O[H].[H]O[H].[H]O[H].COC1=CC=C2[N]3=C([N-]C2=C1)[S](CC(N=CC(C)=C4OC)=C4C)=[O][Mg+2]35[N](C6=CC=C7OC)=C([N-]C6=C7)[S](CC(N=CC(C)=C8OC)=C8C)=[O]5

Molecular Formula

C34H42MgN6O9S2

Molecular Weight

767.17

Precautions

H302, H315, H319, H335

References & Citations

[1]Timothy R Koch, et al. Effect of the H, K-ATPase inhibitor, esomeprazole magnesium, on gut total antioxidant capacity in mice. J Nutr Biochem. 2004 Sep;15 (9) :522-6.|[2]Pankaj Kumar, et al. Preparation and characterization of pH-sensitive methyl methacrylate-g-starch/hydroxypropylated starch hydrogels: in vitro and in vivo study on release of esomeprazole magnesium. Drug Deliv Transl Res. 2015 Jun;5 (3) :243-56.|[3]2013 Annual Meeting. Abstract Supplement|[4]Huarui Zhang, et al. Advances in the discovery of exosome inhibitors in cancer. J Enzyme Inhib Med Chem. 2020 Dec;35 (1) :1322-1330.

Shipping Conditions

Room Temperature

Storage Conditions

4°C (Powder, sealed storage, away from moisture and light)

Scientific Category

Reference compound1

Clinical Information

Launched

Available Sizes

Frequently Asked Questions

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