S- (-) -7-Desmethyl-8-nitro blebbistatin

S- (-) -7-Desmethyl-8-nitro blebbistatin (compound 12) is an analog of (-) -Blebbistatin (HY-13441) . (-) -Blebbistatin is a selective non-muscle myosin II inhibitor[1][2].

Product Specifications

CAS Number

[856925-75-2]

UNSPSC

12352005

Hazard Statement

H302+H312+H332, H315, H317, H319

Target

Drug Derivative

Type

Reference compound

Related Pathways

Others

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/s-minus-7-desmethyl-8-nitro-blebbistatin.html

Purity

99.0

Smiles

O=C1[C@@]2(O)C(N(C3=CC=CC=C3)CC2)=NC4=C1C=CC([N+]([O-])=O)=C4

Molecular Formula

C17H13N3O4

Molecular Weight

323.30

Precautions

H302+H312+H332, H315, H317, H319

References & Citations

[1]Cristina Lucas-Lopez, et al. Absolute Stereochemical Assignment and Fluorescence Tuning of the Small Molecule Tool, (–) -Blebbistatin. Chemistry Europe, 2005, 9: 1736-1740.|[2]Ponsaerts R, et al. The myosin II ATPase inhibitor blebbistatin prevents thrombin-induced inhibition of intercellular calcium wave propagation in corneal endothelial cells. Invest Ophthalmol Vis Sci. 2008 Nov;49 (11) :4816-27.