GSK137647A
GSK137647A (GSK 137647) is a potent, selective free fatty acid receptor 4 (FFA4) agonist with pEC50 values of 6.3, 6.2, and 6.1 for human, mouse and rat FFA4, and pEC50 values [1][2].
Product Specifications
CAS Number
349085-82-1
Product Name Alternative
GSK 137647
UNSPSC
12352005
Hazard Statement
H315, H319, H335
Target
Free Fatty Acid Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/GSK137647A.html
Concentration
10mM
Purity
99.81
Solubility
DMSO : ≥ 100 mg/mL
Smiles
O=S(C1=CC=C(OC)C=C1)(NC2=C(C)C=C(C)C=C2C)=O
Molecular Formula
C16H19NO3S
Molecular Weight
305.39
Precautions
H315, H319, H335
References & Citations
[1]Salaga M, et, al. Activation of Free Fatty Acid Receptor 4 Affects Intestinal Inflammation and Improves Colon Permeability in Mice. Nutrients. 2021 Aug 6;13 (8) :2716. |[2]Sparks SM, et, al. Identification of diarylsulfonamides as agonists of the free fatty acid receptor 4 (FFA4/GPR120) . Bioorg Med Chem Lett. 2014 Jul 15;24 (14) :3100-3.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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