Eliglustat
Eliglustat is an specific, potent and orally active glucocerebroside synthase inhibitor with an IC50 of 24 nM.
Product Specifications
CAS Number
[491833-29-5]
Product Name Alternative
Genz 99067
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Glucosylceramide Synthase (GCS)
Type
Reference compound
Related Pathways
Neuronal Signaling
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease; Cancer
Assay Protocol
https://www.medchemexpress.com/Eliglustat.html
Purity
99.75
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
CCCCCCCC(N[C@H](CN1CCCC1)[C@@H](C2=CC=C(OCCO3)C3=C2)O)=O
Molecular Formula
C23H36N2O4
Molecular Weight
404.54
Precautions
H302, H315, H319, H335
References & Citations
[1]McEachern KA, et al. A specific and potent inhibitor of glucosylceramide synthase for substrate inhibition therapy ofGaucher disease. Mol Genet Metab. 2007 Jul;91 (3) :259-68.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Launched
Citation 01
Cell Death Dis. 2021 Oct 6;12 (10) :911.|EMBO J. 2023 Jan 16;42 (2) :e110553.|Nat Commun. 2020 Aug 27;11 (1) :4279.|Nat Commun. 2024 Aug 14;15 (1) :6970.|PLoS Biol. 2025 Sep 11;23 (9) :e3003362.|Sci Adv. 2025 Oct 31;11 (44) :eaea1212.|bioRxiv. 2021 Feb 2.|Cancer Discov. 2023 Feb 6;13 (2) :454-473.|Immunity. 2021 Jan 12;54 (1) :132-150.e9.|Int J Biol Macromol. 2024 Dec 2:285:138303.|Leiden University. 2022 Jun 15.|PLoS One. 2021 Oct 25;16 (10) :e0247211.|Stem Cells Transl Med. 2021 Jul;10 (7) :1081-1094.
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