Eliglustat
Product Specifications
UNSPSC Description
Eliglustat is an specific, potent and orally active glucocerebroside synthase inhibitor with an IC50 of 24 nM.
Target Antigen
Others
Type
Reference compound
Related Pathways
Others
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease; Cancer
Assay Protocol
https://www.medchemexpress.com/Eliglustat.html
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
CCCCCCCC(N[C@H](CN1CCCC1)[C@@H](C2=CC=C(OCCO3)C3=C2)O)=O
Molecular Weight
404.54
References & Citations
[1]McEachern KA, et al. A specific and potent inhibitor of glucosylceramide synthase for substrate inhibition therapy ofGaucher disease. Mol Genet Metab. 2007 Jul;91(3):259-68.Cell Death Dis. 2021 Oct 6;12(10):911.|EMBO J. 2022 Dec 12;e110553.|Nat Commun. 2020 Aug 27;11(1):4279.|Nat Commun. 2024 Aug 14;15(1):6970.|bioRxiv. 2021 Feb 2.|Cancer Discov. 2022 Nov 4;CD-22-0535.|Immunity. 2021 Jan 12;54(1):132-150.e9.|Leiden University. 2022 Jun 15.|PLoS One. 2021 Oct 25;16(10):e0247211.|Stem Cells Transl Med. 2021 Mar 3.
Shipping Conditions
Room Temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-14885/Eliglustat-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-14885/Eliglustat-SDS-MedChemExpress.pdf
Clinical Information
Launched
CAS Number
491833-29-5
Available Sizes
Curated Selection
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