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Eliglustat

Eliglustat is an specific, potent and orally active glucocerebroside synthase inhibitor with an IC50 of 24 nM.

Product Specifications

CAS Number

[491833-29-5]

Product Name Alternative

Genz 99067

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Glucosylceramide Synthase (GCS)

Type

Reference compound

Related Pathways

Neuronal Signaling

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Metabolic Disease; Cancer

Assay Protocol

https://www.medchemexpress.com/Eliglustat.html

Purity

99.75

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

CCCCCCCC(N[C@H](CN1CCCC1)[C@@H](C2=CC=C(OCCO3)C3=C2)O)=O

Molecular Formula

C23H36N2O4

Molecular Weight

404.54

Precautions

H302, H315, H319, H335

References & Citations

[1]McEachern KA, et al. A specific and potent inhibitor of glucosylceramide synthase for substrate inhibition therapy ofGaucher disease. Mol Genet Metab. 2007 Jul;91 (3) :259-68.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Product Datasheet

http://file.medchemexpress.com/batch_PDF/HY-14885/Eliglustat-DataSheet-MedChemExpress.pdf

Product MSDS

http://file.medchemexpress.com/batch_PDF/HY-14885/Eliglustat-SDS-MedChemExpress.pdf

Scientific Category

Reference compound1

Clinical Information

Launched

Citation 01

Cell Death Dis. 2021 Oct 6;12 (10) :911.|EMBO J. 2023 Jan 16;42 (2) :e110553.|Nat Commun. 2020 Aug 27;11 (1) :4279.|Nat Commun. 2024 Aug 14;15 (1) :6970.|PLoS Biol. 2025 Sep 11;23 (9) :e3003362.|Sci Adv. 2025 Oct 31;11 (44) :eaea1212.|bioRxiv. 2021 Feb 2.|Cancer Discov. 2023 Feb 6;13 (2) :454-473.|Immunity. 2021 Jan 12;54 (1) :132-150.e9.|Int J Biol Macromol. 2024 Dec 2:285:138303.|Leiden University. 2022 Jun 15.|PLoS One. 2021 Oct 25;16 (10) :e0247211.|Stem Cells Transl Med. 2021 Jul;10 (7) :1081-1094.

Available Sizes

Curated Selection

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