Gaboxadol (hydrochloride)
Gaboxadol hydrochloride (Lu 02-030 hydrochloride) is a potent agonist of the GABAA receptor and an antagonist of GABAC receptors (IC50=25 μM) . Gaboxadol hydrochloride displays a partial agonist efficacy on subunit α1β2γ2 with an ED50 value of 143 μM, a full agonist efficacy at α5 subunit (ED50=28-129 μM) and a superagonist efficacy at α4β3δ (ED50=6 μM) . Gaboxadol hydrochloride is a non-opioid agent[1][2].
Product Specifications
CAS Number
85118-33-8
Product Name Alternative
Lu 02-030 (hydrochloride) ; THIP (hydrochloride)
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
GABA Receptor
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/gaboxadol-hydrochloride.html
Purity
99.95
Solubility
DMSO : 75 mg/mL (ultrasonic) |H2O : ≥ 100 mg/mL
Smiles
O=C1C2=C(CNCC2)ON1.Cl
Molecular Formula
C6H9ClN2O2
Molecular Weight
176.60
Precautions
H302, H315, H319, H335
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture and light)
Scientific Category
Reference compound1
Clinical Information
Phase 3
Available Sizes
Frequently Asked Questions
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