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Custirsen

Custirsen is a highly specific antisense oligonucleotide that inhibits the production of clusterin , an antiapoptotic protein that is upregulated in response to chemotherapy and that confers treatment resistance.

Product Specifications

CAS Number

890056-27-6

Product Name Alternative

OGX-011

UNSPSC

12352208

Target

Apoptosis

Type

Oligonucleotides

Related Pathways

Apoptosis

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/custirsen.html

Purity

96.12

Solubility

H2O : 50 mg/mL (ultrasonic)

Smiles

[Custirsen]

Molecular Formula

C231H312N78O119P20S20

Molecular Weight

7346.00

References & Citations

[1]Chi KN, Eisenhauer E, Fazli L, et al. A phase I pharmacokinetic and pharmacodynamic study of OGX-011, a 2'-methoxyethyl antisense oligonucleotide to clusterin, in patients with localized prostate cancer. J Natl Cancer Inst. 2005;97 (17) :1287-1296.

Shipping Conditions

Blue Ice

Storage Conditions

-20°C (Powder, sealed storage, away from moisture)

Scientific Category

Oligonucleotides

Clinical Information

Phase 3

Available Sizes

Frequently Asked Questions

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