Custirsen
Custirsen is a highly specific antisense oligonucleotide that inhibits the production of clusterin , an antiapoptotic protein that is upregulated in response to chemotherapy and that confers treatment resistance.
Product Specifications
CAS Number
890056-27-6
Product Name Alternative
OGX-011
UNSPSC
12352208
Target
Apoptosis
Type
Oligonucleotides
Related Pathways
Apoptosis
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/custirsen.html
Purity
96.12
Solubility
H2O : 50 mg/mL (ultrasonic)
Smiles
[Custirsen]
Molecular Formula
C231H312N78O119P20S20
Molecular Weight
7346.00
References & Citations
[1]Chi KN, Eisenhauer E, Fazli L, et al. A phase I pharmacokinetic and pharmacodynamic study of OGX-011, a 2'-methoxyethyl antisense oligonucleotide to clusterin, in patients with localized prostate cancer. J Natl Cancer Inst. 2005;97 (17) :1287-1296.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, sealed storage, away from moisture)
Scientific Category
Oligonucleotides
Clinical Information
Phase 3
Available Sizes
Frequently Asked Questions
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