KIF18A-IN-3
KIF18A-IN-3 is a potent KIF18A inhibitor (IC50=61 nM) . KIF18A-IN-3 causes significant mitotic arrest and increases the number of mitotic cells in tumor tissues. KIF18A-IN-3 can be used for researching cancer[1].
Product Specifications
CAS Number
2600577-49-7
UNSPSC
12352005
Target
Kinesin; Microtubule/Tubulin
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Cytoskeleton
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/kif18a-in-3.html
Purity
99.30
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(C1=CC=C(NS(C2(C)CC2)(=O)=O)C=C1N3CCC4(CC4)CC3)NC5=CC=CC(S(NC(C)(C)C)(=O)=O)=C5
Molecular Formula
C28H38N4O5S2
Molecular Weight
574.76
References & Citations
[1]Tamayo NA, et al. Targeting the Mitotic Kinesin KIF18A in Chromosomally Unstable Cancers: Hit Optimization Toward an In Vivo Chemical Probe. J Med Chem. 2022;65 (6) :4972-4990.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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