Helianorphin-19

Helianorphin-19 is a potent and selective κ-opioid receptor (KOR) activator with a Ki of 21 nM and an EC50 of 45 nM. Helianorphin-19 exhibits strong KOR-specific peripheral analgesic activity in a mouse model of chronic visceral pain[1].

Product Specifications

CAS Number

[2883653-86-7]

UNSPSC

12352209

Target

Opioid Receptor

Type

Peptides

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/helianorphin-19.html

Solubility

10 mM in DMSO

Smiles

O=C([C@@H](NC1=O)CSSC[C@H](NC2=O)C(N[C@H](C(N[C@H](C(N3[C@H](C(N[C@H](C(N[C@H](C(N[C@H]1CCCCN)=O)CC(C)C)=O)CCCCN)=O)CCC3)=O)CCCNC(N)=N)=O)[C@H](CC)C)=O)N[C@H](C(NCC(NCC(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H]2CCCNC(N)=N)=O)CCCNC(N)=N)=O)CC(C)C)=O)CC4=CC=CC=C4)=O)=O)=O)CC5=CC=C(O)C=C5

Molecular Formula

C81H132N26O16S2

Molecular Weight

1790.21

References & Citations

[1]Muratspahić E, et al. Design of a Stable Cyclic Peptide Analgesic Derived from Sunflower Seeds that Targets the κ-Opioid Receptor for the Treatment of Chronic Abdominal Pain. J Med Chem. 2021 Jul 8;64 (13) :9042-9055.