YKL-05-099

YKL-05-099 is a salt-inducible kinase (SIK) inhibitor. YKL-05-099 binds to SIK1 and SIK3 with IC50s of ~10 and ~30 nM, respectively. YKL-05-099 has slightly less potent SIK2-inhibitory (IC50=40 nM) [1].

Product Specifications

CAS Number

[1936529-65-5]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Salt-inducible Kinase (SIK)

Type

Reference compound

Related Pathways

Immunology/Inflammation

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/YKL-05-099.html

Purity

99.76

Solubility

DMSO : ≥ 75 mg/mL

Smiles

O=C1N(C2=NC=C(OC)C=C2)C3=NC(NC4=CC=C(C5CCN(C)CC5)C=C4OC)=NC=C3CN1C6=C(C)C=CC=C6Cl

Molecular Formula

C32H34ClN7O3

Molecular Weight

600.11

Precautions

H302, H315, H319, H335

References & Citations

[1]Sundberg TB, et al. Development of Chemical Probes for Investigation of Salt-Inducible Kinase Function in Vivo. ACS Chem Biol. 2016 Aug 19;11 (8) :2105-11.