PROTAC SMARCA2 degrader-29

PROTAC SMARCA2 degrader-29 (Example 87) is a PROTAC SMARCA2 (BRM) degrader, with DC50 of 10-100 nM (BRM) and > 1 μM (BRG1, also known as SMARCA2) respectively[1].

Product Specifications

CAS Number

[2865193-25-3]

UNSPSC

12352005

Target

Epigenetic Reader Domain; PROTACs

Type

Reference compound

Related Pathways

Epigenetics; PROTAC

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/protac-smarca2-degrader-29.html

Smiles

CC(C)[C@@H](C(N1C[C@H](O)C[C@H]1C(N[C@@H](C)C2=CC=C(C3=C(C)N=CS3)C=C2)=O)=O)C4=CC(N5CCC(N6CCC(C7=CC8=C(C=C(C9=CC=CC=C9O)N=N8)S7)CC6)CC5)=NO4

Molecular Formula

C47H54N8O5S2

Molecular Weight

875.11

References & Citations

[1]Matthew Netherton, et al. Compounds and uses thereof. Patent. WO2022240825

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Curated Selection

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