KT D606

KT D606 is an inhibitor of the PAK kinase family, with an IC50 value of 4 μM. KT D606 selectively blocks the proliferation of cancer cells transformed by oncogenic RAS mutants and can be used for research on RAS/PAK1-induced cancers[1].

Product Specifications

CAS Number

[1429063-06-8]

UNSPSC

12352005

Target

PAK

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; Cytoskeleton

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/kt-d606.html

Smiles

C[C@]12N3C4=C(C5=CC=CC=C53)C(C(NC6=O)CCCCCCCC7C8=C(C(N7)=O)C9=C%10C%11=C8C%12=CC=CC=C%12N%11[C@](C)([C@](O)(C%13)C(O)=O)O[C@@]%13([H])N%10C%14=CC=CC=C9%14)=C6C%15=C4N([C@](C[C@]2(O)C(O)=O)([H])O1)C%16=CC=CC=C%15%16

Molecular Formula

C59H50N6O10

Molecular Weight

1003.06

References & Citations

[1]Nheu TV, et al. The K252a derivatives, inhibitors for the PAK/MLK kinase family selectively block the growth of RAS transformants. Cancer J. 2002 Jul-Aug;8 (4) :328-36.