DDD85646

DDD85646 (IMP-366) is an orally active of trypanosoma brucei N-myristoyltransferase (TbNMT IC50=2 nM; hNMT IC50=4 nM) . The enzyme N-myristoyltransferase (NMT) is a potential agent target for human African trypanosomiasis[1][2][3][4].

Product Specifications

CAS Number

[1215010-55-1]

Product Name Alternative

IMP-366

UNSPSC

12352005

Target

DNA/RNA Synthesis; Parasite

Type

Reference compound

Related Pathways

Anti-infection; Cell Cycle/DNA Damage

Applications

COVID-19-anti-virus

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/ddd85646.html

Purity

99.72

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=S(C1=C(Cl)C=C(C2=CC(N3CCNCC3)=NC=C2)C=C1Cl)(NC4=C(C)N(C)N=C4C)=O

Molecular Formula

C21H24Cl2N6O2S

Molecular Weight

495.43

References & Citations

[1]Spinks D, et al. Development of Small-Molecule Trypanosoma brucei N-Myristoyltransferase Inhibitors: Discovery and Optimisation of a Novel Binding Mode. ChemMedChem. 2015;10 (11) :1821-1836.|[2]Kallemeijn WW, et al. Validation and Invalidation of Chemical Probes for the Human N-myristoyltransferases. Cell Chem Biol. 2019;26 (6) :892-900.e4.|[3]Frearson JA, et al. N-myristoyltransferase inhibitors as new leads to treat sleeping sickness. Nature. 2010;464 (7289) :728-732.|[4]Paape D, et al. Using a non-image-based medium-throughput assay for screening compounds targeting N-myristoylation in intracellular Leishmania amastigotes. PLoS Negl Trop Dis. 2014 Dec 18;8 (12) :e3363.