8-Hydroxyguanosine

8-Hydroxyguanosine, an oxidized nucleoside, is a marker of RNA oxidative damage and oxidative stress. 8-Hydroxyguanosine stimulates proliferation and differentiation of murine B cells with immunostimulatory activity. 8-Hydroxyguanosine is promising for research of Alzheimer’s disease and Down’s syndrome[1][2][3][4].

Product Specifications

CAS Number

[3868-31-3]

Product Name Alternative

CP 526555-15N,13C,d10,CP 526555 hydrochloride

UNSPSC

12352005

Hazard Statement

H315, H319, H320

Target

Endogenous Metabolite; Interleukin Related

Type

Natural Products

Related Pathways

Immunology/Inflammation; Metabolic Enzyme/Protease

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Metabolic Disease; Inflammation/Immunology; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/8-Hydroxyguanosine.html

Concentration

10mM

Purity

99.91

Solubility

DMSO : 125 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

OC[C@@H]1[C@@H](O)[C@@H](O)[C@H](N2C(NC3=C2N=C(N)NC3=O)=O)O1

Molecular Formula

C10H13N5O6

Molecular Weight

299.24

Precautions

H315, H319, H320

References & Citations

[1]Fiala ES, et al. Oxidative DNA and RNA damage in the livers of Sprague-Dawley rats treated with the hepatocarcinogen 2-nitropropane. Cancer Res. 1989 Oct 15;49 (20) :5518-22.|[2]Abe T, et al. Remarkable increase in the concentration of 8-hydroxyguanosine in cerebrospinal fluid from patients with Alzheimer's disease. J Neurosci Res. 2002 Nov 1;70 (3) :447-50.|[3]Ahmad A, et al. 8-Hydroxyguanosine and 8-methoxyguanosine possess immunostimulating activity for B lymphocytes. Cell Immunol. 1985 Aug;94 (1) :276-80. |[4]Choi S, et al. Anti-inflammatory effects of 8-hydroxy-2'-deoxyguanosine on lipopolysaccharide-induced inflammation via Rac suppression in Balb/c mice. Free Radic Biol Med. 2007 Dec 15;43 (12) :1594-603.