Kukoamine A-d8 (dihydrochloride)
Product Specifications
UNSPSC Description
Kukoamine A-d8 (dihydrochloride) is deuterium labeled Kukoamine A. Kukoamine A is a natural occurring spermine derivative, acts as a potent inhibitor of trypanothione reductase (Ki, 1.8 μM), with antihypertensive activity[1].
Target Antigen
Isotope-Labeled Compounds; Parasite
Type
Isotope-Labeled Compounds
Related Pathways
Anti-infection;Others
Applications
COVID-19-immunoregulation
Field of Research
Infection; Cardiovascular Disease
Solubility
10 mM in DMSO
Smiles
[2H]C([2H])(NCCCNC(CCC1=CC=C(O)C(O)=C1)=O)C([2H])([2H])C([2H])([2H])C([2H])(NCCCNC(CCC2=CC=C(O)C(O)=C2)=O)[2H].Cl.Cl
Molecular Weight
611.63
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.|[2]Ponasik JA, et al. Kukoamine A and other hydrophobic acylpolyamines: potent and selective inhibitors of Crithidia fasciculata trypanothione reductase. Biochem J. 1995 Oct 15;311 ( Pt 2):371-5.
Shipping Conditions
Room temperature
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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