Kukoamine A-d8 (dihydrochloride)

Kukoamine A-d8 (dihydrochloride) is deuterium labeled Kukoamine A. Kukoamine A is a natural occurring spermine derivative, acts as a potent inhibitor of trypanothione reductase (Ki, 1.8 μM), with antihypertensive activity[1].

Product Specifications

UNSPSC

12352005

Target

Isotope-Labeled Compounds; Parasite

Type

Isotope-Labeled Compounds

Related Pathways

Anti-infection; Others

Applications

COVID-19-immunoregulation

Field of Research

Infection; Cardiovascular Disease

Solubility

10 mM in DMSO

Smiles

[2H]C([2H])(NCCCNC(CCC1=CC=C(O)C(O)=C1)=O)C([2H])([2H])C([2H])([2H])C([2H])(NCCCNC(CCC2=CC=C(O)C(O)=C2)=O)[2H].Cl.Cl

Molecular Formula

C28H36D8Cl2N4O6

Molecular Weight

611.63

References & Citations

[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216.|[2]Ponasik JA, et al. Kukoamine A and other hydrophobic acylpolyamines: potent and selective inhibitors of Crithidia fasciculata trypanothione reductase. Biochem J. 1995 Oct 15;311 (Pt 2) :371-5.