BD1063 (dhydrochloride)

BD1063 dhydrochloride is a potent and selective sigma 1 receptor antagonist.

Product Specifications

CAS Number

[206996-13-6]

UNSPSC

12352005

Hazard Statement

H319

Target

Sigma Receptor

Type

Reference compound

Related Pathways

Neuronal Signaling

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/BD1063_dhydrochloride.html

Purity

98.0

Solubility

H2O : 100 mg/mL (ultrasonic)

Smiles

CN1CCN(CCC2=CC=C(Cl)C(Cl)=C2)CC1.Cl.Cl

Molecular Formula

C13H20Cl4N2

Molecular Weight

346.12

Precautions

H319

References & Citations

[1]Sabino V, et al. The sigma-receptor antagonist BD-1063 decreases ethanol intake and reinforcement in animal models of excessive drinking. Neuropsychopharmacology. 2009 May;34 (6) :1482-93.|[2]Cottone P, et al. Antagonism of sigma-1 receptors blocks compulsive-like eating. Neuropsychopharmacology. 2012 Nov;37 (12) :2593-604.|[3]Nieto FR, et al. Role of sigma-1 receptors in paclitaxel-induced neuropathic pain in mice. J Pain. 2012 Nov;13 (11) :1107-21.