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AChE-IN-60

AChE-IN-60 (compound 6k) is a potant acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) inhibitor with IC50s of 27 nM and 43 nM, respectively. AChE-IN-60 also inhibits monoamine oxidase (MAO) -A and MAO-B with IC50s of 353 nM and 716 nM, respectively[1].

Product Specifications

UNSPSC

12352005

Target

Cholinesterase (ChE) ; Monoamine Oxidase

Type

Reference compound

Related Pathways

Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/ache-in-60.html

Solubility

10 mM in DMSO

Smiles

CCCCCCCCOC(C1=CC2=C(N=C(S2)NC(NS(=O)(C3=CC=C(C=C3)C)=O)=S)C=C1)=O

Molecular Formula

C24H29N3O4S3

Molecular Weight

519.70

References & Citations

[1]Nguyen Dinh Thanh, et al. Sulfonyl thioureas with a benzo[d]thiazole ring as dual acetylcholinesterase/butyrylcholinesterase and human monoamine oxidase A and B inhibitors: An in vitro and in silico study. Arch Pharm (Weinheim) . 2024 Feb 6:e2300557.

Shipping Conditions

Room temperature

Product Datasheet

http://file.medchemexpress.com/batch_PDF/HY-157981/AChE-IN-60-DataSheet-MedChemExpress.pdf

Product MSDS

http://file.medchemexpress.com/batch_PDF/HY-157981/

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

AChE; BChE; MAO-A; MAO-B

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