AChE-IN-60
AChE-IN-60 (compound 6k) is a potant acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) inhibitor with IC50s of 27 nM and 43 nM, respectively. AChE-IN-60 also inhibits monoamine oxidase (MAO) -A and MAO-B with IC50s of 353 nM and 716 nM, respectively[1].
Product Specifications
UNSPSC
12352005
Target
Cholinesterase (ChE) ; Monoamine Oxidase
Type
Reference compound
Related Pathways
Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/ache-in-60.html
Solubility
10 mM in DMSO
Smiles
CCCCCCCCOC(C1=CC2=C(N=C(S2)NC(NS(=O)(C3=CC=C(C=C3)C)=O)=S)C=C1)=O
Molecular Formula
C24H29N3O4S3
Molecular Weight
519.70
References & Citations
[1]Nguyen Dinh Thanh, et al. Sulfonyl thioureas with a benzo[d]thiazole ring as dual acetylcholinesterase/butyrylcholinesterase and human monoamine oxidase A and B inhibitors: An in vitro and in silico study. Arch Pharm (Weinheim) . 2024 Feb 6:e2300557.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
AChE; BChE; MAO-A; MAO-B
Frequently Asked Questions
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