LIT-001
LIT-001 is the first nonpeptide oxytocin receptor (OT-R) agonist (EC50=55 nM; Ki=226 nM) . LIT-001 improves social interaction in a mouse model of autism[1].
Product Specifications
CAS Number
[2245072-21-1]
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Oxytocin Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/lit-001.html
Purity
99.91
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(N1[C@H](C(N(C)C)=S)CCC1)NCC2=CC=C(C(N3C4=CC=CC=C4NC(N(C)N=C5)=C5C3)=O)C=C2C.O=C(O)C(F)(F)F
Molecular Formula
C30H34F3N7O4S
Molecular Weight
645.70
Precautions
H302, H315, H319, H335
References & Citations
[1]Frantz MC, et al. LIT-001, the First Nonpeptide Oxytocin Receptor Agonist that Improves Social Interaction in a Mouse Model of Autism. J Med Chem. 2018 Oct 11;61 (19) :8670-8692.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
MBS7063783 Inquire
Recombinant Scheffersomyces stipitis Golgi apparatus membrane protein TVP23 (TVP23), partial
Ask
View Details 
MBS6334550-01 0.1 mL
PLA2G3, CT (PLA2G3, Group 3 secretory phospholipase A2, Group III secretory phospholipase A2, Phosphatidylcholine 2-acylhydrolase 3) (MaxLight 650)
Ask
View Details 
MBS6334550-02 5x 0.1 mL
PLA2G3, CT (PLA2G3, Group 3 secretory phospholipase A2, Group III secretory phospholipase A2, Phosphatidylcholine 2-acylhydrolase 3) (MaxLight 650)
Ask
View Details 038822-APC 200 µL
NCAPG, NT (NCAPG, CAPG, NYMEL3, Condensin complex subunit 3, Chromosome-associated protein G, Condensin subunit CAP-G, Melanoma antigen NY-MEL-3, Non-SMC condensin I complex subunit G, XCAP-G homolog) (APC) discontinued
Ask
View Details