OTSSP167

OTSSP167 (OTS167) is a highly potent and ATP-competitive MELK inhibitor with IC50 value of 0.41 nM.

Product Specifications

CAS Number

[1431697-89-0]

Product Name Alternative

OTS167

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

MELK

Type

Reference compound

Related Pathways

PI3K/Akt/mTOR

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/OTSSP167.html

Purity

99.70

Solubility

DMSO : 2.5 mg/mL (ultrasonic; warming; adjust pH to 4 with 1M HCl; heat to 60°C)

Smiles

ClC1=CC(C2=CC=C(N=CC(C(C)=O)=C3N[C@H]4CC[C@H](CN(C)C)CC4)C3=N2)=CC(Cl)=C1O

Molecular Formula

C25H28Cl2N4O2

Molecular Weight

487.42

Precautions

H302, H315, H319, H335

References & Citations

[1]Chung S, Suzuki H, Miyamoto T, et al. Development of an orally-administrative MELK-targeting inhibitor that suppresses the growth of various types of human cancer. Oncotarget. 2012 Dec 21.|[2]Ji W, et al. OTSSP167 Abrogates Mitotic Checkpoint through Inhibiting Multiple Mitotic Kinases. PLoS One. 2016 Apr 15;11 (4) :e0153518.|[3]Cho YS, et al. The crystal structure of MPK38 in complex with OTSSP167, an orally administrative MELK selective inhibitor. Biochem Biophys Res Commun. 2014 Apr 25;447 (1) :7-11.|[4]Li S, et al. Maternal embryonic leucine zipper kinase serves as a poor prognosis marker and therapeutic target in gastric cancer. Oncotarget. 2016 Feb 2;7 (5) :6266-80.