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Acefylline (piperazine)

Acefylline (Theophyllineacetic acid) piperazine, a xanthine derivative, is an Adenosine Receptor antagonist. Acefylline piperazine is a peptidylarginine deiminase (PAD) activator. Acefylline piperazine is also a bronchodilator and cardiac stimulant that inhibits rat lung cAMP phosphodiesterase isoenzymes. Acefylline piperazine can be used in asthma research[1][2][3].

Product Specifications

CAS Number

18833-13-1

Product Name Alternative

Theophyllineacetic acid (piperazine) ; Theophylline-7-acetic acid (piperazine)

UNSPSC

12352005

Target

Adenosine Receptor; Phosphodiesterase (PDE) ; Protein Arginine Deiminase

Type

Reference compound

Related Pathways

Epigenetics; GPCR/G Protein; Metabolic Enzyme/Protease

Applications

Neuroscience-Neuromodulation

Field of Research

Inflammation/Immunology; Neurological Disease; Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/acefylline-piperazine.html

Smiles

O=C(CN1C=NC2=C1C(N(C)C(N2C)=O)=O)O.N3CCNCC3.[x]

Molecular Formula

C9H10N4O4.xC4H10N2

References & Citations

[1]Ferretti C, et al. Inhibitory effect of theophylline, theophylline-7-acetic acid, ambroxol and ambroxol-theophylline-7-acetate on rat lung cAMP phosphodiesterase isoenzymes. Int J Tissue React. 1992;14 (1) :31-6. |[2]Méchin MC, et, al. Acefylline activates filaggrin deimination by peptidylarginine deiminases in the upper epidermis. J Dermatol Sci. 2016 Feb;81 (2) :101-6.|[3]Tsvetkova B, Tencheva J, Peikov P. Esterification of 7-theophyllineacetic acid with diethylene glycol monomethyl ether. Acta Pharm. 2006 Jun;56 (2) :251-7. PMID: 16613730.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Frequently Asked Questions

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