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BIRT 377

BIRT 377 is a potent amd orally bioavailable inhibitor of the interaction between intercellular adhesion molecule-1 (ICAM-1) and lymphocyte function-associated antigen-1 (LFA-1) . BIRT 377 also inhibits the production of IL-2 in vivo. BIRT 377 can be used for researching inflammatory and immune disorders[1].

Product Specifications

CAS Number

213211-10-0

UNSPSC

12352005

Target

Integrin; Interleukin Related

Type

Reference compound

Related Pathways

Cytoskeleton; Immunology/Inflammation

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/birt-377.html

Purity

99.82

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C1N(C2=CC(Cl)=CC(Cl)=C2)C(N(C)[C@]1(C)CC3=CC=C(Br)C=C3)=O

Molecular Formula

C18H15BrCl2N2O2

Molecular Weight

442.13

References & Citations

[1]Kelly TA, et al. Cutting edge: a small molecule antagonist of LFA-1-mediated cell adhesion. J Immunol. 1999;163 (10) :5173-5177.|[2]Lanzloth R, et al. Mast cells interact directly with colorectal cancer cells to promote epithelial-to-mesenchymal transition[J]. bioRxiv, 2025: 2025.03. 19.644113.|[3]Winquist RJ, et al., The role of leukocyte function-associated antigen-1 in animal models of inflammation. Eur J Pharmacol. 2001 Oct 19;429 (1-3) :297-302.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

IL-2

Available Sizes

Frequently Asked Questions

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