SLUG rabbit pAb

Snail family transcriptional repressor 2 (SNAI2) Homo sapiens This gene encodes a member of the Snail family of C2H2-type zinc finger transcription factors. The encoded protein acts as a transcriptional repressor that binds to E-box motifs and is also likely to repress E-cadherin transcription in breast carcinoma. This protein is involved in epithelial-mesenchymal transitions and has antiapoptotic activity. Mutations in this gene may be associated with sporatic cases of neural tube defects. [provided by RefSeq, Jul 2008],

Product Specifications

Background

UniProt

O43623

Swiss Prot

O43623

Reactivity

Human; Mouse; Rat

Immunogen

Recombinant Protein of SLUG

Clonality

Polyclonal

Source

Rabbit

Applications

WB; IHC; IF

Dilution

WB: 1:500-1000 IHC: 1:200-500

Molecular Weight

30kD

Storage Conditions

-20°C/1 year

Observed Molecular Weight

30kD

Fragment

IgG

Subcellular Location

Nucleus . Cytoplasm. Observed in discrete foci in interphase nuclei. These nuclear foci do not overlap with the nucleoli, the SP100 and the HP1 heterochromatin or the coiled body, suggesting SNAI2 is associated with active transcription or active splicing regions.