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CDK5-IN-4

CDK5-IN-4 (compound 4) is a potent multikinase type-II inhibitor targeting CDK5, with an IC50 of 9.8 μM. CDK5-IN-4 also inhibits GSK-3α, GSK-3β, CDK9, and CDK2, with IC50 values of 0.98, 4.00, 1.76, and 6.24 μM, respectively. CDK5-IN-4 can be used for glioblastoma research[1].

Product Specifications

CAS Number

1212711-91-5

UNSPSC

12352005

Target

CDK; GSK-3

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; PI3K/Akt/mTOR; Stem Cell/Wnt

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/cdk5-in-4.html

Smiles

O=C(N[C@H]1CO[C@@H]2[C@H](CO[C@H]12)NC3=NC(C4=CC=CC(F)=C4)=CC=N3)NCC5=CC=CC=C5

Molecular Formula

C24H24FN5O3

Molecular Weight

449.48

References & Citations

[1]Khan ZR, et al. Discovery of Potent Multikinase Type-II Inhibitors Targeting CDK5 in the DFG-out Inactive State with Promising Potential against Glioblastoma. J Med Chem. 2024 Apr 30.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

CDK2; CDK5; CDK9; GSK-3α; GSK-3β

Frequently Asked Questions

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