PF-4708671
PF-4708671 is a potent cell-permeable S6K1 inhibitor with a Ki of 20 nM and IC50 of 160 nM.
Product Specifications
CAS Number
[1255517-76-0]
UNSPSC
12352005
Hazard Statement
H301
Target
Autophagy; Ribosomal S6 Kinase (RSK)
Type
Reference compound
Related Pathways
Autophagy; MAPK/ERK Pathway
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/PF-4708671.html
Purity
99.87
Solubility
DMSO : 33.33 mg/mL (ultrasonic)
Smiles
FC(C1=CC=C2N=C(CN3CCN(C4=NC=NC=C4CC)CC3)NC2=C1)(F)F
Molecular Formula
C19H21F3N6
Molecular Weight
390.41
Precautions
H301
References & Citations
[1]Pearce LR, et al. Characterization of PF-4708671, a novel and highly specific inhibitor of p70 ribosomal S6 kinase (S6K1) . Biochem J. 2010 Oct 15;431 (2) :245-55.|[2]Zhang Y, et al. Inhibition of p70S6K1 Activation by Pdcd4 Overcomes the Resistance to an IGF-1R/IR Inhibitor in Colon Carcinoma Cells. Mol Cancer Ther. 2015 Mar;14 (3) :799-809.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
P70S6K
Available Sizes
Curated Selection
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