Recombinant Mouse TNFSF11 (RANKL)

Tumor necrosis factor ligand superfamily member 11 (TNFSF11), also known as Receptor Activator of Nuclear factor Kappa-B Ligand (RANKL), is a member of the tumor necrosis factor (TNF) ligand family. RANKL regulates bone remodeling and the development of the thymus, lymph nodes and mammary glands. Mouse TNFSF11 (RANKL) Recombinant Protein is purified TNFSF11 (RANKL) produced in yeast.

Product Specifications

Synonyms

Mouse ; TNFSF11

Label

ICT

Type

Recombinant Protein

Source

Yeast

Sequence

FSGAPAMMEG SWLDVAQRGK PEAQPFAHLT INAASIPSGS HKVTLSSWYH DRGWAKISNM TLSNGKLRVN QDGFYYLYAN ICFRHHETSG SVPTDYLQLM VYVVKTSIKI PSSHNLMKGG STKNWSGNSE FHFYSINVGG FFKLRAGEEI SIQVSNPSLL DPDQDATYFG AFKVQDID (178)

Assay Protocol

The Human IL-19 protein can be used in cell culture, as an IL-19 ELISA Standard, and as a Western Blot Control.

Form

Lyophilized

Shipping Conditions

Shipping: Ships at ambient temperature, Ships overnight (domestic), International Priority Shipping

Storage Temperature

-20°C

Notes

20% discount

Calculated Molecular Weight

19.8 kDa

Target Description

Tumor necrosis factor ligand superfamily member 11 (TNFSF11), also known as Receptor Activator of Nuclear factor Kappa-B Ligand (RANKL), TNF-related activation-induced cytokine (TRANCE), osteoprotegerin ligand (OPGL), and osteoclast differentiation factor (ODF), is a member of the tumor necrosis factor (TNF) ligand family. Nineteen cytokine ligands have been identified as part of the TNF family on the basis of sequence, functional, and structural similarities. Family members include TNF beta (TNFSF1), TNF alpha (TNFSF2), Lymphotoxin beta (TNFSF3), OX40 Ligand (TNFSF4), CD40 Ligand (TNFSF5), Fas Ligand (TNFSF6), CD27 Ligand (TNFSF7), CD30 Ligand (TNFSF8), 4-1BB Ligand (TNFSF9), TRAIL (TNFSF10), TRANCE/RANKL (TNFSF11), TWEAK (TNFSF12), APRIL(TNFSF13), BAFF (TNFSF13B), LIGHT (TNFSF14), TL1A/VEGI (TNFSF15), and GITR Ligand (TNFSF18)., , RANKL regulates bone remodeling and the development of the thymus, lymph nodes and mammary glands. Overproduction of RANKL is implicated in a variety of degenerative bone diseases, such as rheumatoid arthritis and psoriatic arthritis.