Recombinant Mouse CXCL12

CXCL12 was originally described as a vital chemoattractant for B cells and monocytes. CXCL12, also known as interleukin-8, is unlike other chemokines in that it binds to one single chemokine receptor, CXCR4, which itself is recognized by no other chemokines. CXCL12 binds to its receptor CXCR4 to mediate cell-type specific physiological processes, including cellular migration, survival, and apoptosis. CXCL12 is produced physiologically in various tissues, and its receptor CXCR4 is expressed on various haematopoietic and non-haematopoietic cells. CXCL12 and CXCR4 are essential for life as mice deficient in either gene are unable to survive much past birth. CXCL12 and CXCR4 play a role in many different diseases, including cancer, HIV, and rheumatoid arthritis.