BMS-820132

BMS-820132 is an orally active and partial glucokinase (GK) activator with a AC50 of 29 nM. BMS-820132 decreases the glucose levels in glucose tolerance test (OGTT) model in normal rats, but not Zucker diabetic fatty (ZDF) rats. BMS-820132 exhibits pharmacological toxicity secondary to strong GK activation[1][2].

Product Specifications

CAS Number

[1001419-18-6]

UNSPSC

12352005

Target

Glucokinase

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/bms-820132.html

Concentration

10mM

Purity

99.75

Solubility

DMSO : 25 mg/mL (ultrasonic)

Smiles

O=C(NC1=NN(CP(OCC)(OCC)=O)C=C1)C2=CC(OC(C)C)=CC(OC3=NC=C(C(N4CCC4)=O)N=C3)=C2

Molecular Formula

C26H33N6O7P

Molecular Weight

572.55

References & Citations

[1]Shi Y, et al. Discovery of a Partial Glucokinase Activator Clinical Candidate: Diethyl ((3- (3- ((5- (Azetidine-1-carbonyl) pyrazin-2-yl) oxy) -5-isopropoxybenzamido) -1H-pyrazol-1-yl) methyl) phosphonate (BMS-820132) . J Med Chem. 2022;65 (5) :4291-4317.