Anti-Hu CD127 Alexa Fluor® 647
CD127, a 60-90 kDa type I transmembrane glycoprotein, serves as the alpha subunit of the IL-7 receptor. It heterodimerizes with CD132, which is the common interleukin receptor gamma chain. CD127-mediated signaling promotes cell survival and is essential for lymphocyte development, including V (D) J recombination. Defects in CD127 can cause severe combined immunodeficiency (SCID) . It is expressed in common lymphoid progenitors, B and T cell precursors (except CD4/CD8 double positive thymocytes), and mature T cell subpopulations. Majority of CD127-CD4+ T cells are Treg cells.
Product Specifications
Certification
RUO
Target Antigen
CD127
Clone
RHIQB010
Applications
FC (QC tested)
Format
Alexa Fluor® 647
Buffer
Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
Storage Conditions
Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.
Specificity
The recombinant mouse monoclonal antibody rHIQB010 recognizes an extracellular epitope of human CD127, the alpha subunit of IL-7 receptor.
Applications Notes
6
Species
Human
Isotype
Mouse IgG1
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