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Anti-Hu Fc epsilon RIa Purified

FcεRIα serves as the IgE Fc-binding subunit of the high-affinity IgE receptor, expressed on the surface of mast cells and basophils. It associates with one beta and two gamma subunits that contain ITAM sequences in their intracellular domains, that function as docking sites in the process of signalosome forming after FcεRI triggering. Attached IgE gives to the receptor specificity for particular antigens which are target of the type I allergen sensitivity or hypersensitivity reaction, and prolongs stability of the receptor on the cell surface. Under physiological conditions this system protects the body against helminths and other parasites and venom toxins, but when dysregulated, it can lead to undesired allergic reactions and anaphylactic shock.

Product Specifications

Certification

RUO

Target Antigen

Fc epsilon RIa

Clone

AER-37 [CRA1]

Applications

ICC (reported), FC (QC tested), IHC-F (reported)

Concentration

1 mg/mL

Format

Purified

Buffer

Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide

References & Citations

*Metz M, Staubach P, Bauer A, Brehler R, Gericke J, Kangas M, Ashton-Chess J, Jarvis P, Georgiou P, Canvin J, Hillenbrand R, Erpenbeck VJ, Maurer M: Clinical efficacy of omalizumab in chronic spontaneous urticaria is associated with a reduction of FcεRI-positive cells in the skin. Theranostics 2017 Mar 6;7 (5) :1266-1276., URL: https://pubmed.ncbi.nlm.nih.gov/28435464/, *Suzukawa M, Hirai K, Iikura M, Nagase H, Komiya A, Yoshimura-Uchiyama C, Yamada H, Ra C, Ohta K, Yamamoto K, Yamaguchi M: IgE- and FcepsilonRI-mediated migration of human basophils. Int Immunol. 2005 Sep;17 (9) :1249-55. , URL: https://pubmed.ncbi.nlm.nih.gov/16103029/, *Morshed M, Hlushchuk R, Simon D, Walls AF, Obata-Ninomiya K, Karasuyama H, Djonov V, Eggel A, Kaufmann T, Simon HU, Yousefi S: NADPH oxidase-independent formation of extracellular DNA traps by basophils. J Immunol. 2014 Jun 1;192 (11) :5314-23., URL: https://pubmed.ncbi.nlm.nih.gov/24771850/

Storage Conditions

Store at 2-8°C. Do not freeze.

Specificity

The mouse monoclonal antibody AER-37 [CRA1] recognizes an extracellular epitope of the high-affinity IgE receptor I alpha subunit (Fc epsilon RIa) .

Applications Notes

Flow cytometry: Recommended dilution: 1-5 μg/ml.

Species

Human, Non-human primates

Isotype

Mouse IgG2b kappa

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