NE 52-QQ57
NE 52-QQ57 is a selective, and orally available GPR4 antagonist with an IC50 of 70 nM. NE 52-QQ57 has anti-inflammatory activity[1].
Product Specifications
CAS Number
[1401728-56-0]
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
GPR4
Type
Reference compound
Related Pathways
GPCR/G Protein
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/GPR4_antagonist_3.html
Purity
99.89
Solubility
DMSO : 20 mg/mL (ultrasonic; warming; adjust pH to 5 with HCl; heat to 60°C)
Smiles
CCC1=NN(C(C)=CC(C)=N2)C2=C1CC3=CC=C(C4=NN=C(C5CCNCC5)O4)C=C3
Molecular Formula
C24H28N6O
Molecular Weight
416.52
Precautions
H302, H315, H319, H335
References & Citations
[1]Velcicky J, et al. Development of Selective, Orally Active GPR4 Antagonists with Modulatory Effects on Nociception, Inflammation, and Angiogenesis. J Med Chem. 2017 May 11;60 (9) :3672-3683.|[2]Hosford PS, et al. CNS distribution, signalling properties and central effects of G-protein coupled receptor 4. Neuropharmacology. 2018 Aug;138:381-392.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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