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NE 52-QQ57

Product Specifications

UNSPSC Description

NE 52-QQ57 is a selective, and orally available GPR4 antagonist with an IC50 of 70 nM. NE 52-QQ57 has anti-inflammatory activity[1].

Target Antigen

GPR4

Type

Reference compound

Related Pathways

GPCR/G Protein

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/GPR4_antagonist_3.html

Purity

99.89

Solubility

DMSO : 20 mg/mL (ultrasonic;warming;adjust pH to 5 with HCl;heat to 60°C)

Smiles

CCC1=NN(C(C)=CC(C)=N2)C2=C1CC3=CC=C(C4=NN=C(C5CCNCC5)O4)C=C3

Molecular Weight

416.52

References & Citations

[1]Velcicky J, et al. Development of Selective, Orally Active GPR4 Antagonists with Modulatory Effects on Nociception, Inflammation, and Angiogenesis. J Med Chem. 2017 May 11;60(9):3672-3683.|[2]Hosford PS, et al. CNS distribution, signalling properties and central effects of G-protein coupled receptor 4. Neuropharmacology. 2018 Aug;138:381-392.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Product Datasheet

http://file.medchemexpress.com/batch_PDF/HY-101784/NE-52-QQ57-DataSheet-MedChemExpress.pdf

Product MSDS

http://file.medchemexpress.com/batch_PDF/HY-101784/NE-52-QQ57-SDS-MedChemExpress.pdf

Clinical Information

No Development Reported

CAS Number

1401728-56-0

Available Sizes

Curated Selection

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