NE 52-QQ57

NE 52-QQ57 is a selective, and orally available GPR4 antagonist with an IC50 of 70 nM. NE 52-QQ57 has anti-inflammatory activity[1].

Product Specifications

CAS Number

[1401728-56-0]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

GPR4

Type

Reference compound

Related Pathways

GPCR/G Protein

Applications

COVID-19-immunoregulation

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/GPR4_antagonist_3.html

Purity

99.89

Solubility

DMSO : 20 mg/mL (ultrasonic; warming; adjust pH to 5 with HCl; heat to 60°C)

Smiles

CCC1=NN(C(C)=CC(C)=N2)C2=C1CC3=CC=C(C4=NN=C(C5CCNCC5)O4)C=C3

Molecular Formula

C24H28N6O

Molecular Weight

416.52

Precautions

H302, H315, H319, H335

References & Citations

[1]Velcicky J, et al. Development of Selective, Orally Active GPR4 Antagonists with Modulatory Effects on Nociception, Inflammation, and Angiogenesis. J Med Chem. 2017 May 11;60 (9) :3672-3683.|[2]Hosford PS, et al. CNS distribution, signalling properties and central effects of G-protein coupled receptor 4. Neuropharmacology. 2018 Aug;138:381-392.