MK-761 (free base)
MK-761 free base is a potent and orally active β2-adrenergic blocker. MK-761 free base shows antihypertensive and positive inotropic effects. MK-761 free base shows vasodilating properties[1].
Product Specifications
CAS Number
65321-41-7
UNSPSC
12352005
Target
Adrenergic Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/mk-761-free-base.html
Purity
99.56
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
N#CC1=CC=CN=C1OC[C@H](CNC(C)(C)C)O
Molecular Formula
C13H19N3O2
Molecular Weight
249.31
References & Citations
[1]Scriabine A, et al. Antihypertensive and cardiac effects of two novel beta-adrenoceptor blocking drugs. Experientia. 1979 Dec 15;35 (12) :1634-7. |[2]C.S. Sweet, et al. Peripheral Vasodilator and β-Adrenoceptor Blocking Properties of Several β-Adrenoceptor Antagonists. Clinical and Experimental Hypertension. 2009, 449-471.|[3]Sweet CS, et al. Beta adrenoceptor blocking properties of MK-761. J Pharmacol Exp Ther. 1979 Oct;211 (1) :195-9.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
β adrenergic receptor
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