Isoxsuprine-d6 (hydrochloride)

Isoxsuprine-d6 (hydrochloride) is the deuterium labeled Isoxsuprine hydrochloride. Isoxsuprine hydrochloride is a beta-adrenergic receptor agonist with Kis of 13.65 μΜ and 3.48 μΜ for myometrial and placcntal beta-adrenergic receptor, respectively. Isoxsuprine hydrochloride is also a NMDA receptor antagonist.

Product Specifications

CAS Number

[2706004-35-3]

UNSPSC

12352005

Hazard Statement

H302

Target

Adrenergic Receptor; iGluR; Isotope-Labeled Compounds

Type

Isotope-Labeled Compounds

Related Pathways

GPCR/G Protein; Membrane Transporter/Ion Channel; Neuronal Signaling; Others

Field of Research

Neurological Disease; Endocrinology

Purity

99.9

Solubility

10 mM in DMSO|DMSO : ≥ 5mg/mL

Smiles

OC(C(NC(C([2H])([2H])[2H])([2H])C([2H])([2H])OC1=CC=CC=C1)C)C2=CC=C(O)C=C2.[H]Cl

Molecular Formula

C18H18D6ClNO3

Molecular Weight

343.88

Precautions

H302

References & Citations

[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216. |[2]Falkay G, et al. Affinity of tocolytic agents on human placental and myometrial beta-adrenergic receptors. J Perinat Med. 1986;14 (2) :109-13.|[3]Kretschy N, et al. In vitro inhibition of breast cancer spheroid-induced lymphendothelial defects resembling intravasation into the lymphatic vasculature by acetohexamide, isoxsuprine, nifedipin and proadifen. Br J Cancer. 2013 Feb 19;108 (3) :570-8.|[4]Hill JW, et al. Identification of isoxsuprine hydrochloride as a neuroprotectant in ischemic stroke through cell-based high-throughput screening. PLoS One. 2014 May 7;9 (5) :e96761.