Rolipram
Product Specifications
UNSPSC Description
Rolipram is a selective phosphodiesterases PDE4 inhibitor with IC50s of 3 nM, 130 nM and 240 nM for PDE4A, PDE4B, and PDE4D, respectively.
Target Antigen
Bacterial; HIV; Phosphodiesterase (PDE)
Type
Reference compound
Related Pathways
Anti-infection;Metabolic Enzyme/Protease
Applications
Cancer-Kinase/protease
Field of Research
Neurological Disease; Cancer
Assay Protocol
https://www.medchemexpress.com/Rolipram.html
Solubility
DMSO : ≥ 41 mg/mL|H2O : < 0.1 mg/mL (ultrasonic;warming;heat to 60°C)
Smiles
O=C1NCC(C2=CC=C(OC)C(OC3CCCC3)=C2)C1
Molecular Weight
275.348
References & Citations
[1]MacKenzie SJ, et al. Action of rolipram on specific PDE4 cAMP phosphodiesterase isoforms and on the phosphorylation of cAMP-response-element-binding protein (CREB) and p38 mitogen-activated protein (MAP) kinase in U937 monocyticcells. Biochem J. 2000 Apr|[2]Korhonen R, et al. Attenuation of TNF production and experimentally induced inflammation by PDE4 inhibitor rolipram is mediated by MAPK phosphatase-1. Br J Pharmacol. 2013 Aug;169(7):1525-36.|[3]Shalaby AM, et al. Effect of rolipram, a phosphodiesterase enzyme type-4 inhibitor, on γ-amino butyric acid content of the frontal cortex in mice exposed to chronic mild stress. J Pharmacol Pharmacother. 2012 Apr;3(2):132-7.
Shipping Conditions
Room Temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-16900/Rolipram-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-16900/Rolipram-SDS-MedChemExpress.pdf
Clinical Information
Phase 2
CAS Number
61413-54-5
Available Sizes
Curated Selection
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