What is the catalog number for Rolipram?

The catalog number for Rolipram is HY-16900.

What sizes are available for Rolipram?

Rolipram is available in the following size(s): 5 mg, 10 mg, 10 mM - 1 mL, 50 mg, 100 mg.

How many pack sizes does Rolipram come in?

Rolipram is available in 5 different pack sizes.

Is Rolipram in stock?

Rolipram is currently made to order / not held in immediate stock. Contact us for lead time.

Who manufactures Rolipram?

Rolipram is manufactured by QuantiMol.

What is the estimated delivery time for Rolipram?

Estimated delivery time for Rolipram is approximately 15 business day(s), depending on your location.

Where can I find the safety data sheet (SDS/MSDS) for Rolipram?

The safety data sheet for Rolipram is available here: http://file.medchemexpress.com/batch_PDF/HY-16900/Rolipram-SDS-MedChemExpress.pdf.

Rolipram

Rolipram is a selective phosphodiesterases PDE4 inhibitor with IC50s of 3 nM, 130 nM and 240 nM for PDE4A, PDE4B, and PDE4D, respectively.

Product Specifications

CAS Number

61413-54-5

Product Name Alternative

(R, S) -Rolipram; (±) -Rolipram; ZK 62711

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Bacterial; HIV; Phosphodiesterase (PDE)

Type

Reference compound

Related Pathways

Anti-infection; Metabolic Enzyme/Protease

Applications

Cancer-Kinase/protease

Field of Research

Neurological Disease; Cancer

Assay Protocol

https://www.medchemexpress.com/Rolipram.html

Purity

99.45

Solubility

DMSO : ≥ 41 mg/mL|H2O : < 0.1 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

O=C1NCC(C2=CC=C(OC)C(OC3CCCC3)=C2)C1

Molecular Formula

C16H21NO3

Molecular Weight

275.35

Precautions

H302, H315, H319, H335

References & Citations

[1]MacKenzie SJ, et al. Action of rolipram on specific PDE4 cAMP phosphodiesterase isoforms and on the phosphorylation of cAMP-response-element-binding protein (CREB) and p38 mitogen-activated protein (MAP) kinase in U937 monocyticcells. Biochem J. 2000 Apr|[2]Korhonen R, et al. Attenuation of TNF production and experimentally induced inflammation by PDE4 inhibitor rolipram is mediated by MAPK phosphatase-1. Br J Pharmacol. 2013 Aug;169 (7) :1525-36.|[3]Shalaby AM, et al. Effect of rolipram, a phosphodiesterase enzyme type-4 inhibitor, on γ-amino butyric acid content of the frontal cortex in mice exposed to chronic mild stress. J Pharmacol Pharmacother. 2012 Apr;3 (2) :132-7.