Hedgehog IN-6
Hedgehog IN-6 (Compound Q29) is a Hedgehog (Hh) inhibitor that can be used in cancer research. Hedgehog IN-6 inhibits the hedgehog (Hh) pathway by binding to the cysteine-rich domain (CRD) of Smoothened (Smo) and blocking its cholesterization[1].
Product Specifications
CAS Number
2916444-33-0
UNSPSC
12352211
Target
Hedgehog; Smo
Type
Reference compound
Related Pathways
Stem Cell/Wnt
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/hedgehog-in-6.html
Solubility
10 mM in DMSO
Smiles
CC1=C(CCC(NCCCC)=O)[C@]2([H])CC[C@@]3([H])C(C)(C)[C@@H](O)CC[C@]3(C)[C@@]2([H])CC1
Molecular Formula
C25H43NO2
Molecular Weight
389.61
References & Citations
[1]Liu YB, et al. A sterol analog inhibits hedgehog pathway by blocking cholesterylation of smoothened. Cell Chem Biol. 2024 Feb 28:S2451-9456 (24) 00076-X.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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