Anti-SOX2 Antibody

Store at 4°C in the dark. Under these conditions, the antibodies should have a shelf life of at least twelve months, provided they remain sterile. For longer term storage, aliquot and freeze to avoid freeze-thaw of the antibody.

SOX2, short for SRY (Sex-Determining Region Y)-Box 2, belongs to the SOX family of proteins which play essential roles in cell differentiation, development, and organogenesis. A transcription factor, SOX2 aids in the embryonic formation of the central nervous system and neural progenitor cells. It helps to maintain the pluripotency of embryonic stem cells, allowing them to differentiate. In adult tissues, SOX2 aids in neural tissue regeneration and repair, as well as the maintenance of adult neural stem cells and their ability to develop into different specialized cell types, essential for neural plasticity. Mutations or dysregulation of SOX2 have been linked to a range of neurological diseases, including neurodevelopmental disorders like aniridia (Matsushima 2011), and optic nerve hypoplasia and septo-optic dysplasia (McCabe 2010). SOX2 has also be implicated in certain brain tumors, particularly in gliomas, where its dysregulation can contribute to uncontrolled cell proliferation (Mansouri 2016).

Each new lot of this antibody is tested to confirm that it recognizes a single immunoreactive band of expected molecular weight when used to probe brain lysate.