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Anti-SOX2 Antibody

Our anti-SOX2 chicken primary antibody from Aves Labs is manufactured in-house. It detects SOX2, and is affinity purified. It is provided in liquid form.

Product Specifications

Background

SOX2, short for SRY (Sex-Determining Region Y) -Box 2, belongs to the SOX family of proteins which play essential roles in cell differentiation, development, and organogenesis. A transcription factor, SOX2 aids in the embryonic formation of the central nervous system and neural progenitor cells. It helps to maintain the pluripotency of embryonic stem cells, allowing them to differentiate. In adult tissues, SOX2 aids in neural tissue regeneration and repair, as well as the maintenance of adult neural stem cells and their ability to develop into different specialized cell types, essential for neural plasticity. Mutations or dysregulation of SOX2 have been linked to a range of neurological diseases, including neurodevelopmental disorders like aniridia (Matsushima 2011), and optic nerve hypoplasia and septo-optic dysplasia (McCabe 2010) . SOX2 has also be implicated in certain brain tumors, particularly in gliomas, where its dysregulation can contribute to uncontrolled cell proliferation (Mansouri 2016) .

Synonyms

Sex Determining Region Y-Box 2, Transcription Factor SOX-2, SRY-Box Transcription Factor 2, SRY-Box 2, MCOPS3, ANOP3, SRY-Related HMG-Box Gene 2

Other Statements

These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.

Gene Name

SOX2

UniProt

P48431

Host

Chicken

Species Reactivity

Human, Mouse, Rat

Reactivity

Human, Mouse, and Rat

Immunogen

His tagged full length protein

Immunogen Type

Human

Target

SOX2

Clonality

Polyclonal

Isotype

IgY

Epitope

Not determined

Conjugation

Unconjugated

Applications

ICC, IHC, WB

Field of Research

Cell Markers Neuronal Markers Transcription Regulation

Assay Type

Primary Antibody

Assay Protocol

Eggs from hens hyperimmunized with target were used to prepare an IgY fraction which was then subjected to antigen-specific affinity purification

Concentration

0.2 mg/ml

Format

Affinity-Purified IgY

Form

Affinity-Purified IgY

Buffer

Phosphate-buffered (10 mM) isotonic (0.9%, w/v) saline (“PBS, " pH 7.2) with sodium azide (0.02%, w/v) added as a preservative.

Molecular Weight

35 kDa

Precautions

These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.

Shipping Conditions

Ice Packs

Storage Conditions

Store at 4°C in the dark. Under these conditions, the antibodies should have a shelf life of at least twelve months, provided they remain sterile. For longer term storage, aliquot and freeze to avoid freeze-thaw of the antibody.

Product Datasheet

https://cdn.shopify.com/s/files/1/0512/5793/4009/files/SOX2_datasheet.pdf?v=1697167110

WB Dilution

1:500-1:1000

Specificity

No cross-reactivity reported

Pre Treatment

Eggs from hens hyperimmunized with target were used to prepare an IgY fraction which was then subjected to antigen-specific affinity purification

Target Description

SOX2, short for SRY (Sex-Determining Region Y)-Box 2, belongs to the SOX family of proteins which play essential roles in cell differentiation, development, and organogenesis. A transcription factor, SOX2 aids in the embryonic formation of the central nervous system and neural progenitor cells. It helps to maintain the pluripotency of embryonic stem cells, allowing them to differentiate. In adult tissues, SOX2 aids in neural tissue regeneration and repair, as well as the maintenance of adult neural stem cells and their ability to develop into different specialized cell types, essential for neural plasticity. Mutations or dysregulation of SOX2 have been linked to a range of neurological diseases, including neurodevelopmental disorders like aniridia (Matsushima 2011), and optic nerve hypoplasia and septo-optic dysplasia (McCabe 2010). SOX2 has also be implicated in certain brain tumors, particularly in gliomas, where its dysregulation can contribute to uncontrolled cell proliferation (Mansouri 2016).

ICC Dilution

1:100-1:500

Quality Control

Each new lot of this antibody is tested to confirm that it recognizes a single immunoreactive band of expected molecular weight when used to probe brain lysate.

Brid

AB_3068326

Uniprot Accession Number

P48431

Physical Properties

Liquid

Isotype

IgY

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