CDK2, Human (His)

CDK2 is an important serine/threonine protein kinase that plays a critical regulatory role in the cell cycle, especially during meiosis. It phosphorylates various substrates (CTNNB1, USP37, p53/TP53, NPM1, CDK7, RB1, BRCA2, MYC, NPAT, EZH2) and coordinates centrosome duplication and initiation of DNA synthesis at the G1-S transition. CDK2 Protein, Human (His) is the recombinant human-derived CDK2 protein, expressed by E. coli , with N-6*His labeled tag. The total length of CDK2 Protein, Human (His) is 298 a.a., with molecular weight of 32-35 kDa.

ENFQKVEKIG EGTYGVVYKA RNKLTGEVVA LKKIRLDTET EGVPSTAIRE ISLLKELNHP NIVKLLDVIH TENKLYLVFE FLHQDLKKFM DASALTGIPL PLIKSYLFQL LQGLAFCHSH RVLHRDLKPQ NLLINTEGAI KLADFGLARA FGVPVRTYTH EVVTLWYRAP EILLGCKYYS TAVDIWSLGC IFAEMVTRRA LFPGDSEIDQ LFRIFRTLGT PDEVVWPGVT SMPDYKPSFP KWARQDFSKV VPPLDEDGRS LLSQMLHYDP NKRISAKAAL AHPFFQDVTK PVPHLRL