TLR4-IN-C34
TLR4-IN-C34 is an orally active TLR4 inhibitor and reduces systemic inflammation in models of endotoxemia and necrotizing enterocolitis[1][2].
Product Specifications
CAS Number
40592-88-9
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Toll-like Receptor (TLR)
Type
Reference compound
Related Pathways
Immunology/Inflammation
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/tlr4-in-c34.html
Concentration
10mM
Purity
99.90
Solubility
DMSO : 200 mg/mL (ultrasonic) |H2O : 33.33 mg/mL (ultrasonic)
Smiles
O=C(N[C@H]([C@@H](OC(C)=O)[C@H](OC(C)=O)[C@@H](COC(C)=O)O1)[C@H]1OC(C)C)C
Molecular Formula
C17H27NO9
Molecular Weight
389.40
Precautions
H302, H315, H319, H335
References & Citations
[1]Neal MD, et al. Discovery and validation of a new class of small molecule Toll-like receptor 4 (TLR4) inhibitors. PLoS One. 2013 Jun 12;8 (6) :e65779.|[2]Wipf P, et al. Synthesis of anti-inflammatory α-and β-linked acetamidopyranosides as inhibitors of toll-like receptor 4 (TLR4) . Tetrahedron Lett. 2015 Jun 3;56 (23) :3097-3100.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
TLR4
Available Sizes
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