Adenosine 5′-diphosphoribose (sodium)

Adenosine 5′-diphosphoribose sodium (ADP ribose sodium) is a nicotinamide adenine nucleotide (NAD+) metabolite. Adenosine 5′-diphosphoribose sodium is the most potent and primary intracellular Ca2+-permeable cation TRPM2 channel activator. Adenosine 5′-diphosphoribose sodium also can enhance autophagy[1][2].

Product Specifications

CAS Number

[68414-18-6]

Product Name Alternative

ADP ribose (sodium)

UNSPSC

12352005

Hazard Statement

H315, H319, H335

Target

Autophagy; TRP Channel

Type

Reference compound

Related Pathways

Autophagy; Membrane Transporter/Ion Channel; Neuronal Signaling

Applications

Cancer-programmed cell death

Field of Research

Endocrinology; Metabolic Disease; Cancer

Assay Protocol

https://www.medchemexpress.com/adenosine-5-diphosphoribose-sodium.html

Purity

99.47

Solubility

DMSO : 25 mg/mL (ultrasonic; warming; heat to 80°C) |H2O : 125 mg/mL (ultrasonic)

Smiles

O[C@H]([C@@H]1O)[C@@H](O[C@@H]1COP(OP(OC[C@@H](O)[C@@H](O)[C@@H](O)C=O)([O-])=O)(O)=O)N2C(N=CN=C3N)=C3N=C2.[Na+]

Molecular Formula

C15H22N5NaO14P2

Molecular Weight

581.30

Precautions

H315, H319, H335

References & Citations

[1]Zhang DX, et al. The potential regulatory roles of NAD (+) and its metabolism in autophagy. Metabolism. 2016 Apr;65 (4) :454-62.|[2] Tóth B, et al. Pore collapse underlies irreversible inactivation of TRPM2 cation channel currents. Proc Natl Acad Sci U S A. 2012 Aug 14;109 (33) :13440-5.