TN-16
TN-16 is a potent inhibitor of microtubule polymerization with IC50 of 0.4-1.7 µM[1].
Product Specifications
CAS Number
[33016-12-5]
Product Name Alternative
Rovamycin
UNSPSC
12352005
Hazard Statement
H317, H400
Target
Microtubule/Tubulin
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Cytoskeleton
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/tn-16.html
Purity
99.78
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
O=C(NC(C/1=O)CC2=CC=CC=C2)C1=C(C)/NC3=CC=CC=C3
Molecular Formula
C19H18N2O2
Molecular Weight
306.36
Precautions
H317, H400
References & Citations
[1]Arai T. Inhibition of microtubule assembly in vitro by TN-16, a synthetic antitumor drug. FEBS Lett. 1983 May 8;155 (2) :273-6.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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