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NSC1011

NSC1011 is a potent Ras converting enzyme 1 endoprotease (Rce1) inhibitor with an IC50 value of 6.9 µM for HsRce1 (crystal structure of the human Rce1) . NSC1011 induces mislocalizing EGFR-H-Ras, EGFR-N-Ras, and EGFR-K-Ras[1].

Product Specifications

CAS Number

5335-97-7

UNSPSC

12352005

Target

Others

Type

Reference compound

Related Pathways

Others

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/nsc1011.html

Smiles

O=C(C1=CC=C(C=C1)NC(C2=CC=CC=C2)C3=CC=C4C=CC=NC4=C3O)O

Molecular Formula

C23H18N2O3

Molecular Weight

370.40

References & Citations

[1]Mohammed I, et al. 8-Hydroxyquinoline-based inhibitors of the Rce1 protease disrupt Ras membrane localization in human cells. Bioorg Med Chem. 2016 Jan 15;24 (2) :160-78.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Frequently Asked Questions

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