Rondaptivon pegol sodium

Rondaptivon pegol (BT200) sodium, a pegylated form of the aptamer BT100, inhibits binding of von Willebrand factor (VWF) to platelet glycoprotein GPIb, preventing arterial thrombosis[1].

Product Specifications

Product Name Alternative

BT200 sodium

UNSPSC

12352208

Target

Integrin

Type

Oligonucleotides

Related Pathways

Cytoskeleton

Applications

Neuroscience-Neuromodulation

Field of Research

Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/bt200-sodium.html

Purity

95.01

Solubility

10 mM in H2O

Smiles

[Rondaptivonpegolsodium]

References & Citations

[1]Zhu S, Gilbert JC, Liang Z, et al. Potent and rapid reversal of the von Willebrand factor inhibitor aptamer BT200. J Thromb Haemost. 2020;18 (7) :1695-1704. |[2]Zhu S, Gilbert JC, Hatala P, et al. The development and characterization of a long acting anti-thrombotic von Willebrand factor (VWF) aptamer. J Thromb Haemost. 2020;18 (5) :1113-1123. |[3]Ay C, Kovacevic KD, Kraemmer D, et al. The von Willebrand factor-binding aptamer rondaptivon pegol as a treatment for severe and nonsevere hemophilia A. Blood. 2023;141 (10) :1147-1158. |[4]Chion A, Byrne C, Atiq F, et al. The aptamer BT200 blocks interaction of K1405-K1408 in the VWF-A1 domain with macrophage LRP1. Blood. 2024;144 (13) :1445-1456.