Lomitapide (mesylate)

Lomitapide (AEGR-733; BMS-201038) mesylate is a highly effective MTP protein inhibitor with an in vitro IC50 value of 8nM.

Product Specifications

CAS Number

[202914-84-9]

Product Name Alternative

AEGR-733 mesylate; BMS-201038 mesylate

UNSPSC

12352005

Hazard Statement

H302-H312-H332

Target

Microsomal Triglyceride Transfer Protein (MTP)

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Neuroscience-Neuromodulation

Field of Research

Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/Lomitapide-mesylate.html

Purity

99.61

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C(C1(CCCCN2CCC(NC(C3=CC=CC=C3C4=CC=C(C(F)(F)F)C=C4)=O)CC2)C5=C(C6=C1C=CC=C6)C=CC=C5)NCC(F)(F)F.O=S(C)(O)=O

Molecular Formula

C40H41F6N3O5S

Molecular Weight

789.83

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P363-P501

References & Citations

[1]Sulsky R, et al. 5-Carboxamido-1,3,2-dioxaphosphorinanes, potent inhibitors of MTP. Bioorg Med Chem Lett. 2004 Oct 18;14 (20) :5067-70.|[2]Lomitapide. Am J Cardiovasc Drugs. 2011 Oct 1;11 (5) :347-52.|[3]Perry CM. Lomitapide: a review of its use in adults with homozygous familial hypercholesterolemia. Am J Cardiovasc Drugs. 2013 Aug;13 (4) :285-96.