N-acetyldopamine

N-acetyldopamine is a sepiapterin reductase inhibitor. N-acetyldopamine is a catecholamine that is used by insects as sclerotizing precursors to harden their cuticle. N-acetyldopamine can attenuate LPS-stimulated TNF-α production and superoxide production in THP-1 cells[1][2].

Product Specifications

CAS Number

[2494-12-4]

Product Name Alternative

NADA

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Endogenous Metabolite; Reactive Oxygen Species (ROS) ; TNF Receptor

Type

Natural Products

Related Pathways

Apoptosis; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/n-acetyldopamine.html

Purity

99.36

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

CC(NCCC1=CC=C(O)C(O)=C1)=O

Molecular Formula

C10H13NO3

Molecular Weight

195.22

Precautions

H302, H315, H319, H335

References & Citations

[1]Hanine Barek, et al. Unraveling Complex Molecular Transformations of N-β-alanyldopamine That Account for Brown Coloration of Insect Cuticle. Rapid Commun Mass Spectrom. 2017 Aug 30;31 (16) :1363-1373.|[2]Perianayagam, M. C., et al., (2005) . Immune-modulating effects of melatonin, N-acetylserotonin, and N-acetyldopamine. Annals of the New York Academy of Sciences, 1053, 386–393.